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Adipokines in Physiology and Pathology of Female Reproduction

Call for Papers

Obesity affects reproductive axis of women throughout their lifespan. For example, underweight women have delayed puberty and higher risk of premature delivery, whereas overweight and obese women have early puberty and are prone to develop polycystic ovary syndrome (PCOS). Moreover, obese women are at higher risk for multiple cancers, including endometrial, cervical, breast, and ovarian cancers.

For the scientist, adipose tissue represents an intriguing endocrine organ that is vital for reproductive function. Adipose tissue releases a variety of factors, termed adipokines (leptin, adiponectin, resistin, visfatin, chemerin, and apelin) that act either locally (paracrine or autocrine action) or systemically (endocrine action). The adipokines regulate energy homeostasis and undoubtedly affect female fertility. For example, leptin alters GnRH and gonadotropin production and has a complexity of roles in the functioning of the ovary and endometrium, as well as in embryo development.

The main focus of this special issue will be on adipokines in physiology and pathology of reproductive tissue. We welcome authors to submit original research articles, review articles, and clinical studies that address these issues. Potential topics include, but are not limited to:

  • The role of adipokines in reproductive tissue physiology
    • Central effects on the hypothalamus and pituitary
    • Peripheral effects on the ovary and reproductive tract
    • Direct effects on the oocyte and the embryo and development
    • Effects during pregnancy
  • The role of adipokines in reproductive tissue pathology
    • Adipokines and ovulatory dysfunction (PCOS)
    • Adipokines and the placenta and pregnancy dysfunction
    • Adipokines and cancer

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/ije/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/ije/frep/ according to the following timetable:

Manuscript DueFriday, 29 November 2013
First Round of ReviewsFriday, 21 February 2014
Publication DateFriday, 18 April 2014

Lead Guest Editor

  • Anna Ptak, Department of Physiology and Toxicology of Reproduction, Jagiellonian University, Krakow, Poland

Guest Editors

  • Joёlle Dupont, Unitȳ de Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, Nouzilly, France
  • Agnieszka Rak-Mardyła, Department of Physiology and Toxicology of Reproduction, Jagiellonian University, Krakow, Poland
  • Georgios Valsamakis, Endocrine Unit, 2nd Department of Obstetrics and Gynaecology, Aretaieion University Hospital, Athens Medical School, Athens, Greece