Where Do Phosphosites Come from and Where Do They Go after Gene Duplication?

Figure 2

Phosphosites that are differentially lost in paralogous phosphoproteins evolve toward negatively charged residues. Each bar represents the percentage of sites (pSer and pThr, cSer and cThr) that evolved from or to Asp or Glu. Numbers above the bars represent the total number of pSer, cSer, pThr, or cThr sites that were gained or lost. Numbers above the arrows indicate 𝑃-values of the Fisher’s exact tests, bold ones being below 0.05.