Positive Selection and the Evolution of izumo Genes in Mammals

Figure 3

Amino acid sequence alignment of IZUMO1 for species of the superorder Laurasiatheria. Distribution of positively selected sites (see asterisks) with posterior probability higher than 90% (grey background/italic font) and 95% (black background/white font). The izumo domain is boxed (single black line), the immunoglobulin domain is double underlined, and the transmembrane domain is underlined by a dotted line. Two letters are used to indicate species: Bull/Cow (Bos taurus—Bt), Cat (Felis catus—Fc), Dog (Canis lupus familiaris—Cf), Horse (Equus caballus—Ec), Megabat (Pteropus vampyrus—Pv), Panda (Ailuropoda melanoleuca—Am), and Pig (Sus scrofa—Ss).