Research Article

Mycobacterium tuberculosis H37Rv: In Silico Drug Targets Identification by Metabolic Pathways Analysis

Table 1

Unique pathways of M. tuberculosis when compared to H. sapiens.

S. no.Pathway nameHumanMycobacterium  tuberculosis H37Rv

1Carbohydrate Metabolism
1.1 C5-Branched dibasic acid metabolismAbsentPresent
2Energy Metabolism
2.1 PhotosynthesisAbsentAbsent
2.2 Carbon fixation pathways in prokaryotesAbsentPresent
2.3 Methane metabolismAbsentPresent
3Lipid Metabolism
3.1 Fatty acid elongation in mitochondriaPresentAbsent
3.2 Sphingolipid metabolismPresentAbsent
3.3 Arachidonic acid metabolismPresentAbsent
4Nucleotide MetabolismAll PresentAll Present
5Amino Acid MetabolismAll PresentAll Present
6Metabolism of Other Amino AcidsAll PresentAll Present
6.1 Phosphonate and phosphinate metabolismAbsentAbsent
7Glycan Biosynthesis and Metabolism
7.1 N-Glycan biosynthesisPresentAbsent
7.2 Various types of N-glycan biosynthesisAbsent
7.3 Mucin type O-Glycan biosynthesisPresentAbsent
7.4 Other types of O-glycan biosynthesisPresentAbsent
7.5 Glycosaminoglycan biosynthesis—chondroitin sulfatePresentAbsent
7.6 Glycosaminoglycan biosynthesis—heparan sulfatePresentAbsent
7.7 Glycosaminoglycan biosynthesis—keratan sulfatePresentAbsent
7.8 Glycosaminoglycan degradationPresentAbsent
7.9 Glycosylphosphatidylinositol (GPI)-anchor biosynthesisPresentAbsent
7.10 Glycosphingolipid biosynthesis—lacto and neolacto seriesPresentAbsent
7.11 Glycosphingolipid biosynthesis—globo seriesPresentAbsent
7.12 Glycosphingolipid biosynthesis—ganglio seriesPresentAbsent
7.13 Lipopolysaccharide biosynthesisAbsentPresent
7.14 Peptidoglycan biosynthesisAbsentPresent
7.15 Other Glycan degradationPresentAbsent