Research Article
Clinical Utility of Cognistat in Multiprofessional Team Evaluations of Patients with Cognitive Impairment in Swedish Primary Care
Table 3
Diagnostic accuracy of the tests.
| | Test cutoff | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | AUC (95% CI) | value (AUC) | CUI+ | Youden Index (J) |
| | Cognistat ≥1 subtest | 0.85 (0.75–0.92) | 0.79 (0.65–0.88) | 0.85 (0.75–0.92) | 0.79 (0.65–0.88) | 0.82 (0.72–0.92) | <0.001 | 0.72 (good) | 0.64 (0.41–0.78) | | Cognistat ≥2 subtests | 0.57 (0.48–0.59) | 0.97 (0.85–0.99) | 0.96 (0.82–1.00) | 0.62 (0.54–0.63) | 0.77 (0.66–0.87) | <0.001 | 0.55 (satisfactory) | 0.54 (0.33–0.58) | | MMSE ≤26 | 0.59 (0.49–0.63) | 0.91 (0.78–0.98) | 0.90 (0.76–0.97) | 0.61 (0.52–0.66) | 0.75 (0.64–0.86) | <0.001 | 0.53 (satisfactory) | 0.50 (0.27–0.61) | | MMSE ≤23 | 0.26 (0.19–0.26) | 1.00 (0.90–1.00) | 1.00 (0.72–1.00) | 0.49 (0.44–0.49) | 0.63 (0.51–0.75) | <0.049 | 0.26 (poor) | 0.26 (0.09–0.26) | | CDT ≤4 | 0.26 (0.17–0.32) | 0.88 (0.76–0.96) | 0.75 (0.50–0.91) | 0.46 (0.40–0.50) | 0.57 (0.44–0.70) | <0.292 | 0.20 (poor) | 0.14 (−0.07–0.28) | | MMSE + CDT ≤26 and ≤4 | 0.70 (0.60–0.77) | 0.79 (0.65–0.89) | 0.82 (0.70–0.91) | 0.65 (0.53–0.74) | 0.74 (0.63–0.85) | <0.001 | 0.57 (satisfactory) | 0.48 (0.24–0.66) | | MMSE + CDT ≤23 and ≤4 | 0.46 (0.36–0.51) | 0.88 (0.75–0.96) | 0.84 (0.66–0.95) | 0.54 (0.46–0.59) | 0.67 (0.55–0.79) | <0.001 | 0.39 (poor) | 0.34 (0.11–0.47) |
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AUC, area under the receiver operating characteristic curve; CDT, Clock Drawing Test; CI, confidence interval; CUI, Clinical Utility Index; MMSE, Mini-Mental State Examination; NPV, negative predictive value; PPV, positive predictive value.
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