Research Article

Global Transcriptional Analysis of Yeast Cell Death Induced by Mutation of Sister Chromatid Cohesin

Table 4

List of differentially expressed genes in time point 2 response to DNA damage (bold = genes differently expressed in both time points).

GeneFold changeDescription
mcd1-1pds5-1

PSO214.936.969.19Required for a postincision step in repair of DNA breaks
CST913.934.0014.93SUMO E3 ligase
EAF713.002.469.85Subunit of the NuA4 histone acetyltransferase complex
MIG312.134.2914.93Probable transcriptional repressor
EPL112.133.738.57Component of NuA4
NHP6A12.133.738.57High-mobility group non-histone chromatin protein
SCC412.132.309.19Subunit of cohesin loading factor (Scc2p-Scc4p)
SLX111.312.8310.56Subunit of 5'-flap endonuclease complex
VID2110.564.5913.00Component of the NuA4 histone acetyltransferase complex
YKU8010.563.259.85Subunit of the telomeric Ku complex (Yku70p-Yku80p)
RAD599.196.509.19Involved in repair of DNA double-strand breaks
HPR59.192.839.19DNA helicase and DNA-dependent ATPase
SIR49.192.837.46Silent information regulator that,
EAF69.192.467.46Esa1p-associated factor, subunit of the NuA4 acetyltransferase complex
TFB39.192.149.19Subunit of TFIIH and nucleotide excision repair factor 3 complexes
NTG18.573.487.46DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase
MGT18.572.649.19DNA repair methyltransferase
SNF58.572.649.19Subunit of the SWI/SNF chromatin remodeling complex
HMI18.572.466.96Mitochondrial inner-membrane localized ATP-dependent DNA helicase
RTT1078.572.007.46Interacts with Mms22p and is implicated in Mms22-dependent DNA repair
EXO18.002.648.005'-3' exonuclease and flap-endonuclease
ELC18.002.1411.31Elongin C
HEX38.002.146.96Protein containing a RING finger domain that interacts with Slx8p
DOA18.002.008.57WD repeat protein
MMS48.002.008.00Subunit of the structure-specific Mms4p-Mus81p endonuclease
RAD167.465.288.00Recognizes and binds damaged DNA in an ATP-dependent manner
MEC37.462.836.96DNA damage and meiotic pachytene checkpoint protein
PIN47.462.469.19Involved in G2/M phase progression and response to DNA damage
CAC27.462.008.57Component of the chromatin assembly complex
LCD16.963.487.46Essential protein required for the DNA integrity checkpoint pathways
PAN26.962.3012.13Subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex