International Journal of Genomics

Research Article

Global Transcriptional Analysis of Yeast Cell Death Induced by Mutation of Sister Chromatid Cohesin

Table 1

List of differentially regulated genes that are related to mitochondria functions in time point 1 (Bold = genes appeared in both time points; ^* = only those localized in mitochondria).


	Gene name	Fold change			Description
	Gene name		mcd1	pds5-1	Description

Localized only in mitochondria	CYC7	13.93	2.64	9.85	Cytochrome c isoform 2
	OM14	11.31	3.25	14.93	Integral mitochondrial outer membrane protein
	ALD4	9.19	2.64	19.70	Mitochondrial aldehyde dehydrogenase
	LSC2	8.57	2.30	9.85	Beta subunit of succinyl-CoA ligase
	CEM1	8.57	2.30	11.31	Mitochondrial beta-keto-acyl synthase
	STF1	8.57	2.46	9.85	Involved in regulation of the mitochondrial F1F0-ATP synthase
	RSM19	8.00	2.14	8.00	Mitochondrial ribosomal protein of the small subunit
	OM45	8.00	3.03	16.00	Major constituent of the mitochondrial outer membrane
	CYB2	8.00	4.00	12.13	Cytochrome b2 (L-lactate cytochrome-c oxidoreductase)
	YME2	7.46	2.00	7.46	Integral inner mitochondrial membrane protein
	MRPL19	7.46	2.00	8.57	Mitochondrial ribosomal protein of the large subunit
	SLM5	7.46	2.14	9.19	Mitochondrial asparaginyl-tRNA synthetase
	AEP1	6.96	2.00	7.46	Required for expression of the mitochondrial OLI1 gene
	FMP46	6.96	2.00	10.56	Putative redox protein containing a thioredoxin fold
	MBR1	6.96	3.73	9.85	Involved in mitochondrial functions and stress response
	ODC1	6.06	2.00	9.19	Mitochondrial inner membrane transporter
	GLT1	−3.48	−2.00	−2.46	NAD(+)-dependent glutamate synthase

Localized in mitochondria and nucleus/cytoplasm	NTH2	13.93	2.00	10.56	Putative neutral trehalase
	GCV1	11.31	2.83	12.13	T subunit of the mitochondrial glycine decarboxylase complex
	GOR1	9.85	2.00	10.56	Glyoxylate reductase
	DIA4	9.19	2.30	8.57	Probable mitochondrial seryl-tRNA synthetase
	RSF1	8.00	2.30	8.57	Protein required for respiratory growth
	YHL009W-B	8.00	2.83	8.57	Retrotransposon TYA Gag and TYB Pol genes
	NTG1	6.96	2.30	7.46	DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase
	ELG1	6.96	2.30	10.56	Required for S phase progression and telomere homeostasis
	LRG1	−2.46	−2.30	−3.25	Putative GTPase-activating protein (GAP)

Of unknown functions	TMA10	19.70	7.46	13.93	Protein of unknown function that associates with ribosomes
	^*YPL222W	12.13	2.30	9.85	The authentic, nontagged protein was localized to the mitochondria.
	^*YDR379C-A	10.56	2.83	10.56	Hypothetical protein identified by homology.
	UIP4	8.57	2.64	19.70	Protein of unknown function that interacts with Ulp1p
	^*YDR070C	8.57	9.85	22.63	The authentic, nontagged protein was localized to the mitochondria
	^*YOR205C	8.00	2.00	9.85	The authentic, nontagged protein was localized to the mitochondria
	^*YHL021C	7.46	2.14	6.96	The authentic, nontagged protein was localized to the mitochondria
	*^YDR332W**	7.46	2.64	11.31	Hypothetical protein
	YML128C	7.46	6.06	22.63	Protein of unknown function
	^*YJL062W-A	6.96	2.14	8.57	Putative protein of unknown function
	^*YNR040W	6.96	2.30	8.57	Hypothetical protein
	^*YNL195C	6.96	3.03	27.86	Hypothetical protein