Global Transcriptional Analysis of Yeast Cell Death Induced by Mutation of Sister Chromatid Cohesin

Table 6

List of differentially expressed genes that are related to mitochondria functions in time point 2, (bold = genes appeared in both time points; ^* = only those localized in mitochondria).

	Gene name	Fold change			Description
		H2O2	mcd1-1	pds5-1
Localized only in mitochondria	CRC1	27.86	32.00	9.85	Mitochondrial inner membrane carnitine transporter
	PUT1	16.00	32.00	8.57	Proline oxidase
	HXT14	13.00	9.19	9.85	Hexose transport
	UBP16	11.31	2.46	8.57	Ubiquitin-dependent protein catabolism
	AAC1	11.31	8.00	8.57	Mitochondrial inner membrane ADP/ATP translocator
	PGS1	10.56	2.83	7.46	Phosphatidylglycerolphosphate synthase
	YHL009W-A	10.56	3.48	9.19	DNA-mediated transposition
	GCV2	9.19	2.64	12.13	P subunit of the mitochondrial glycine decarboxylase complex
	AEP1	9.19	3.48	11.31	Protein biosynthesis
	HTD2	9.19	3.73	8.00	Mitochondrial 3-hydroxyacyl-thioester dehydratase
	HMI1	8.57	2.46	6.96	Mitochondrial ATP-dependent DNA helicase
	ARG2	7.46	2.64	9.85	Acetylglutamate synthase
	GLT1	−2.64	−3.48	−2.64	NAD(+)-dependent glutamate synthase
	ILV5	−3.03	−2.14	−3.48	Acetohydroxyacid reductoisomerase
	POR2	−3.03	−2.00	−2.00	Ion transport
Localized in mitochondria and nucleus/cytoplasm	JJJ1	16.00	2.14	21.11	endocytosis
	HSF1	12.13	3.73	9.19	Trimeric heat shock transcription factor
	SPC105	9.85	3.03	7.46	Protein required for accurate chromosome segregation
	GCV1	9.85	8.00	8.00	T subunit of the mitochondrial glycine decarboxylase complex
	NTH2	9.19	5.28	9.19	Putative neutral trehalase
	VPS15	8.57	2.00	7.46	Myristoylated serine/threonine protein kinase
	VPS54	8.57	2.00	8.00	Component of the Golgi-associated retrograde protein complex
	PTC5	8.57	2.00	8.57	Mitochondrially localized type 2C protein phosphatase
	LAS1	8.57	2.00	12.13	Essential nuclear protein possibly involved in morphogenesis
	BIR1	8.57	2.46	8.57	Cell cycle, anti-apoptotic
	ELG1	8.57	2.46	12.13	Required for S phase progression and telomere homeostasis
	NTG1	8.57	3.48	7.46	DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase
	AFT2	8.57	3.73	8.57	Iron-regulated transcriptional activator
	RIS1	8.00	2.46	7.46	Member of the SWI/SNF family of DNA-dependent ATPases
	GYP1	8.00	3.03	8.57	Vesicle-mediated transport
	SUR7	−2.83	−2.14	−3.48	Putative integral membrane protein
	MRH1	−2.83	−2.00	−2.83	Protein that localizes primarily to the plasma membrane
Of unknown functions	^*YNL130C-A	18.38	8.57	12.13	Protein of unknown function
	^*YBR047W	13.93	4.29	8.57	Protein of unknown function
	^*YLR346C	11.31	11.31	14.93	Protein of unknown function
	^*YLR253W	9.85	2.46	8.00	Protein of unknown function
	TOF2	9.85	3.03	13.93	Protein of unknown function
	^*YDR332W	9.85	4.92	7.46	Hypothetical protein
	^*YGL226W	8.57	2.30	8.00	Protein of unknown function
	^*YOR305W	8.00	2.00	9.19	Protein of unknown function