Table 1: Summary of altered gene expression in mice infected with WT Y. pestis CO92, or its lpp mutant, compared to uninfected control animals.

TissueControl versus WTWT versus Mutant
12 hours48 hours12 hours48 hours
UpDownUpDownUpDownUpDown

Number of Genes

Liver333996644156120136
Lung371016230109
Spleen444771916

A dash (“—") indicates that no gene expression differences were deemed as statistically significant (fold-change 1.5, value ). Note that 57% (109 out of 192) of WT Y. pestis-induced host transcriptional responses in the lungs of mice infected for 48 hours were perturbed in the absence of lpp.