Table 3: Comparison of transcriptional alterations in mice infected with WT Y. pestis CO92 (this study) and a strain that is avirulent in humans (Y. pestis strain 201, previous study reported by Liu et al. [21]).

This studyLiu et al.
GeneFCTissueGeneFCTissue

CD343.7LiverCD342.2Liver
Ifitm13.3AllIfitm32.7Liver
Ifitm64.4Lung
Tgfbr22.3LiverTgfb32.5Liver
−3Lung
Tnfsf102.3LiverTnfrsf1a2.3Liver
Tnfrsf13b2.3Lung
Ccl202.4LungCcl207.5Lung
Cd1412.5AllCd1414.1Lung & Liver
Csf36.6AllCsf35Lung
Cxcl239.8Lung & LiverCxcl214.2Lung & Liver
Cxcl5/69.5AllCxcl5/62.6Lung
IL-1b5.6AllIL-1b4.8Lung
IL2rg2.9LiverIL2rb2.5Lung
Tnfaip82LiverTnfaip82.3Lung
Cd92.8LiverCd92.4Liver
−2.6Lung
Icam22.8LiverIcam21.9Liver
−3.1Lung
IFN- 4.6AllIFN- −2.2Lung
Igfbp13.7LiverIgfbp13.2Liver
Igfbp42.1
Lbp4.2LiverLbp4.2Liver
Ndrg−2LiverNdrg1Up?
Gadd45g8.3LiverGadd45gUp?
MT15.1Lung & LiverMT1UpLung & Liver
MT29.2Lung & LiverMT2UpLung & Liver

For this study, fold changes (FCs) shown are averages across affected tissues. Only alterations that were determined to be statistically significant (i.e., Benjamini and Hochberg corrected value and absolute consistency across all replicate experiments) are included. A negative sign before values indicates downregulation.