International Journal of Genomics

Research Article

Comparative Analyses of Transcriptional Profiles in Mouse Organs Using a Pneumonic Plague Model after Infection with Wild-Type Yersinia pestis CO92 and Its Braun Lipoprotein Mutant

Table 4

Selected gene expression alterations in the liver, lung, and spleen of mice infected with a lpp mutant of Y. pestis CO92, compared to WT Y. pestis.


GenBank ID	Gene Name	WT versus Mut	C versus WT	C versus Mut
			FC

Liver 12 hours

K01391	B.subtilis tryptophan (trp) operon, complete cds.	25.9	—	25.9
BB449248	Apoptosis inhibitor 5 (Api5)	3.0	—	2.8
L38424	Bacillus subtilis dihydropicolinate reductase (jojE)	−167.8	—	−226.1

GenBank ID	Gene Name	WT versus Mut	C versus WT	C versus Mut

Spleen 12 hours

BB167641	Cyclin D3 (Ccnd3)	−4.2	3.8	—
BC027056	Microtubule-associated protein, RP/EB family, member 2 (Mapre2)	−2.6	2.0	—
BB636266	Nemo like kinase (Nlk)	−2.3	2.1	—
NM_013743	Pyruvate dehydrogenase kinase, isoenzyme 4 (Pdk4)	−2.7	3.1	—
AF402617	BCL2-antagonist/killer 1 (Bak1)	3.1	−2.2	—
NM_009743	Bcl2-like 1 (Bcl2l1)	2.4	−2.3	—
NM_010438	Hexokinase 1 (Hk1)	4.8	−4.8	—
AY058908	Anti-human CD37 antibody WR17 kappa light chain variable region	4.0	−2.4	1.6
L41881	Immunoglobulin kappa chain variable 28 (V28) (Igk-V28)	3.8	−1.8	2.1
BG141874	Transthyretin (Ttr)	3.1		3.2

Liver 48 hours

AK014526	Lipin 1 (Lpin1)	−1.8	2.3
BE685667	Cyclin D3 (Ccnd3)	2		2.1
AF169388	Procollagen, type IV, alpha 4 (Col4a4)	2		3.0
BB305930	Protocadherin 17 (Pcdh17)	2.2		3.0
BM122301	Transforming growth factor, beta receptor III (Tgfbr3)	1.8		2.6
BC025105	V-set and immunoglobulin domain containing 4 (Vsig4)	−2.3	—	−2.8
NM_015780	Complement factor H-related 1 (Cfhr1)	−2.9		−3.4

Lung 48 hours

BC011338	Baculoviral IAP repeat-containing 3 (Birc3)	1.83	—	2.2
L16462	B-cell leukemia/lymphoma 2 related protein A1a (Bcl2a1a)	2.34	—	3.5
NM_007651	CD53 antigen (Cd53)	1.99	—	2.1
AF252873	Chemokine (C-X-C motif) ligand 14 (Cxcl14)	2.71	—	2.7
BC024886	Coagulation factor III (F3)	2.18	—	2.4
NM_007972	Coagulation factor X (F10)	2.41	—	3
BM238701	Dual specificity phosphatase 16 (Dusp16)	2.63	—	2.7
NM_007913	Early growth response 1 (Egr1)	3.03	—	3
AF065917	Leukemia inhibitory factor (Lif)	3.36	—	4.7
BB491008	MARCKS-like 1	2.96	—	3.6
BB730139	Prostaglandin E synthase (Ptges)	2.55	—	3

Fold changes (FCs) shown were statistically significant (i.e., Benjamini and Hochberg corrected value and absolute consistency across all replicate experiments). A negative sign before values indicates downregulation. A dash “—" indicates that no statistical difference was observed. WT and mutant (Mut) refer to wild-type Y. pestis CO92 and its lpp mutant, respectively. C: control (uninfected) mice.