|
| Family | Function |
|
| Highly represented families | |
| JakA | Receptor tyrosine kinase. Activates STAT involved in interferon signaling [7] |
| Lmr | Receptor tyrosine kinase involved in apoptosis [8] |
| PDGFR | Receptor tyrosine kinase activating factors for growth, differentiation, development [7] |
| Eph | Receptor tyrosine kinase component of developmental pathways [9] |
| InsR | Receptor that binds insulin and has a tyrosine-protein kinase activity [10] |
| PIM | Phosphorylating chromatin proteins and controlling transcription [11] |
| CDKL | Mediates phosphorylation of MECP2 [12] |
| Trio | Guanine nucleotide exchange factors that mediate cell invasiveness [13] |
| DYRK | Directs cellular response to stress conditions and also implicated in neuropathological characteristics of Down’s syndrome [14, 15] |
| Trk | Receptor for neurotrophin-3 (NT-3) [16] |
| Src | Nonreceptor protein tyrosine kinase that plays pivotal roles in numerous cellular processes such as proliferation, migration, and transformation [17] |
| VEGFR | The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability [18] |
| Sgk496 | Induces both caspase-dependent apoptosis and caspase-independent cell death [19] |
| Trbl | Interacts with MAPK kinases and regulates activation of MAP kinases [20] |
| Wnk | Controls sodium and chloride ion transport [21] |
|
| Underrepresented families | |
| KIS | Function unknown |
| MLCK | Calcium/calmodulin-dependent enzyme implicated in smooth muscle contraction via phosphorylation of myosin light chains [22] |
| MLK | Involved in the JNK pathway [23] |
| MAPKAPK | Integrative element of signaling in both mitogen and stress responses [24] |
| CDK | Involved in regulation of cell cycle by binding to cyclins [25] |
| CAMKK | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes [26] |
| Ste7 | MAP2K homologous to yeast Ste7 [27] |
|
