Research Article
Empirical Bayes Model Comparisons for Differential Methylation Analysis
Table 3
Time-dependent methylation pattern definitions. Between the parent A2780 cell and its cisplatin-treated 1st, 3rd, and 5th generation daughter cells, a probe with increased methylation (probability ≥ 0.8) is defined as hypermethylation (i.e., up), a probe with decreased methylation (probability ≥ 0.8) is defined as hypomethylation (i.e., down), and otherwise, the methylation change is even. Probes showing decreased methylation from generations 1 to 3 to 5 were defined as having “stochastic hypomethylation.” Analogously, probes showing increased methylation from generations 1 to 3 to 5 were considered to exhibit “stochastic hypermethylation.” Finally, probes showing mixed increased and decreased methylation from generations 1 to 3 to 5 were defined as having “random differential methylation.”
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||