The Stability of the Induced Epigenetic Programs

Table 1

Chromatin- and transcription- related complexes involved in maintaining ES cells pluripotency. The main reported activity of the complex is indicated; however, notice that specific subunits might carry out enzymatic activities different than the main described activity.

Complex	Main activity	Subunit	Reported function
Polycomb
PRC1	H2AK119 ubiquitination	Ring1B	Restrains Pol II at bivalent genes avoiding premature differentiation [3]
		CBX7	Maintenance of pluripotency regulating PRC1 targets [4]
PRC2	H3K27 methylation	Ezh2/1	Repression of differentiation genes [5]
		Eed	Repression of differentiation genes [5–7]
		Suz12	Repression of differentiation genes and needed during differentiation [8, 9]
		JARID2	Recruitment of Polycomb to target genes [10]
		RBP2	Mediates H3K4me demethylation at bivalent genes [11]
BAF	Nucleosome remodelling	Brg1	Coactivator of the pluripotency network [12]
NuRD	Nucleosome remodelling	Mbd3	Nucleosome stabilization at bivalent domains [13]
INO80	Nucleosome remodelling	INO80	Co-activator of the pluripotency network [14]
CHD1	Nucleosome remodelling	Chd1	Co-activator of the pluripotency network [15, 16]
MLL	H3K4 methylation	UTX/jmjd3	H3K27me demethylation of bivalent domains [17]
		Dpy-30	Participates in the induction of developmental genes during differentiation [18]
		WDR5	Co-activator of the pluripotency network [19]
CoREST	Histone deacetylase	LSD1	H3K4me demethylation of bivalent domains [20]
Mediator	Transcription activation	Med12	Co-activator of the pluripotency network [21]