Table 3: Biological pathways controlled by IR-modulated miRNAs and their association with ionizing radiation response.

Identified pathways Number of miRNA target genes Association with IR response Reference Adherens junction 10 Yes [42] Aldosterone-regulated sodium reabsorption 7 Unknown N/A Apoptosis 9 Yes [38] Cell cycle 12 Yes [41] Endocytosis 20 Yes [35] Focal adhesion 17 Yes [43] Insulin signaling 19 Yes [37] Long-term potentiation 11 Unknown N/A MAPK signaling 22 Yes [33] Neutrotrophin signaling 12 Unknown N/A Oocyte meiosis 13 Yes [44] p53 signaling 8 Yes [39] Regulation of actin cytoskeleton 20 Yes [34] Renal cell carcinoma 9 Yes [45] TGF-β signaling 10 Yes [40] Thyroid cancer 6 Yes [46] Ubiquitin-mediated proteolysis 17 Yes [47]