Comparative Genome Sequence Analysis Reveals the Extent of Diversity and Conservation for Glycan-Associated Proteins in Burkholderia spp.

Table 4

Surface glycan associated proteins that showed significant reactivity during infection.

GeneDB ID	Protein names	Subcellular location	Pathogenic description	Reference
BPSL1902	Putative membrane protein	S-Layer	Cross-reactive antigen	Felgner et al. [43]
BPSL1705	Putative membrane protein	Outer membrane/extracellular	Serodiagnostic antigen	Felgner et al. [43]
BPSS2053	Putative cell surface protein	Outer membrane	Cross-reactive antigen	Felgner et al. [43]
BPSS1434	Putative membrane-anchored cell surface protein	Outer membrane/extracellular	Cross-reactive antigen	Felgner et al. [43]
BPSS1439	Putative membrane-anchored cell surface protein	Outer membrane	Strong antibody response^U	Tiyawisutsri et al. [44]

Serodiagnostic antigens: antigens that exhibit significantly different reactivity levels between the Singapore melioidosis positive and negative cohorts.
Cross-reactive antigens: antigens that are equally reactive in both melioidosis positive and negative individuals, healthy subjects from endemic or nonendemic areas, or patients with other infections.
^UStrong antibody response: the experiment was carried out using the protein in B. mallei which is ortholog for BPSL1439. This protein in B. mallei exhibits strong antibody response during experimental glanders.