The Distribution of eIF4E-Family Members across Insecta

Figure 1

Seven eIF4E cognates in D. melanogaster. (A) ClustalW alignment of amino acid sequences representing Class I eIF4E family members from D. melanogaster. An extended version of eIF4E-6, not detected in previous studies, is included. Identical (blue) or conservative (gray) amino acid residues in at least 70% of sequences are highlighted. Conservative substitutions groups are STA, or NEQK, or NHQK, or NDEQ, or QHRK, or MILV, or MILF, or HY, or FYW, or GA. Residues essential for eIF4G- and 4E-BP binding are marked *; residues involved in cap binding are marked lower case c; phosphorylatable Ser, as well as Lys described to form a salt bridge with P-Ser, are marked lower case p.