RUNX Family Participates in the Regulation of p53-Dependent DNA Damage Response

Figure 4

Knockdown of RUNX2 enhances ADR-mediated apoptotic cell death in U2OS cells. U2OS cells were transiently transfected with control siRNA or with siRNA targeting RUNX2. Twenty-four hours after transfection, cells were exposed to ADR or left untreated. Twenty-four hours after ADR exposure, cells were observed by phase-contrast microscopy.