Molecular Analysis of Twist1 and FGF Receptors in a Rabbit Model of Craniosynostosis: Likely Exclusion as the Loci of Origin
Figure 4
SNP discovery and genotyping of FGFR2 in craniosynostotic rabbits. We identified a FGFR2 SNP within exon 9, a silent mutation, that segregates independently of craniosynostosis within our colony, ruling out FGFR2 as the causative agent. ((a)–(c)) Sequencing traces representing G/G (a), A/A (b), or G/A (c) genotypes from CS genomic DNA. (d) Results of sequencing of 22 randomly selected CS animals; five animals were G/G genotype, seven animals were A/A, and ten animals were G/A.
