TSP-1-1223 A/G Polymorphism as a Potential Predictor of the Recurrence Risk of Bladder Cancer in a Chinese Population

Table 6

Interaction analyses of the TSP-1-1223 A/G polymorphism and tobacco smoking.

Smoking status	Genotypes	Cases		Controls		𝑃^a	Crude OR (95% CI)^a	𝑃^b	Adjusted OR (95% CI)^b
		𝑛	%	𝑛	%
Nonsmokers	AA + AG	278	45.7	377	56.3		1.00 (reference)		1.00 (reference)
Nonsmokers	GG	39	6.4	49	7.3	0.738	1.08 (0.67–1.73)	0.381	1.25 (0.76–2.05)
Smokers	AA + AG	254	41.7	215	32.1	<0.001	1.60 (1.25–2.05)	0.001	1.58 (1.20–2.10)
Smokers	GG	38	6.2	29	4.3	0.025	1.78 (1.04–3.06)	0.158	1.52 (0.85–2.73)
𝑃Interaction (multiplicative)									0.823

CI: confidence interval; OR: odds ratio.
^aTwo-sided 𝜒² test for either genotype distributions or allele frequencies between the cases and controls.
^bAdjusted for age, gender, smoking, drinking status, and family history of cancer in logistic regression model.