TSP-1-1223 A/G Polymorphism as a Potential Predictor of the Recurrence Risk of Bladder Cancer in a Chinese Population

Table 8

Genotype and allele frequencies of the TSP-1-1223 A/G polymorphism among the bladder cancer cases with survival information.

Genotypes	Recurrence (𝑛=78)		Nonrecurrence (𝑛=158)		𝑃^b	Adjusted HR (95% CI)^b
	𝑛	%	𝑛	%
AA	25	32.1	79	50.0		1.00 (reference)
AG	33	42.3	58	36.7	0.062	1.68 (0.97–2.88)
GG	20	25.6	21	13.3	0.002	2.63 (1.43–4.83)
AA	25	32.1	79	50.0		1.00 (reference)
AG + GG	53	67.9	79	50.0	0.007	1.95 (1.20–3.19)
AG + AA	58	74.4	137	86.7		1.00 (reference)
GG	20	25.6	21	13.3	0.006	2.07 (1.23–3.49)
A allele	83	53.2	216	63.4
G allele	73	46.8	100	36.6		𝑃^a=𝟎.𝟎𝟎𝟏

CI: confidence interval; HR: hazard ratio.
^aTwo-sided 𝜒² test for allele frequencies between the cases and controls.
^bAdjusted for age, gender, smoking, drinking status, and family history of cancer in cox regression model.
The bold font refers to the statistical significance of result.