DUSP1 Gene Polymorphisms Are Associated with Obesity-Related Metabolic Complications among Severely Obese Patients and Impact on Gene Methylation and Expression

Table 2

Characteristics of DUSP1 sequence variations identified by direct sequencing in 25 severely obese individuals.

rs number	Other designation^a	Region	MAF	HWE; P value
rs322381	c. −1534C>T	Promoter	0.02	1.00
—	c. −1430G>A	Promoter	0.38	0.006
rs13184134	c. −1411C>T	Promoter	0.14	1.00
rs322382	c. −997A>G	Promoter	0.30	1.00
rs881150	c. −950A>T	Promoter	0.26	0.96
—	c. −648G>T	Promoter	0.02	1.00
rs2070996	c. −545C>T	Promoter	0.16	1.00
rs28372789	c. −333delA	Promoter	0.46	0.06
—	c. 106A>C; p.Asn36His	Exon 1	0.02	1.0
—	c. 120C>T; p.Ile40Ile	Exon 1	0.02	1.0
rs200878863	c. 158G>T; p.Arg53Leu	Exon 1	0.02	1.0
rs201026723	c. 180G>C; p.Met60Ile	Exon 1	0.04	1.0
rs34507926	c. 367+8C>G	Intron 1	0.04	1.0
rs35084382	c. 513+125A>G	Intron 2	0.02	1.0
rs7702178	c. 513+167A>G	Intron 2	0.16	1.0
rs2431663	c. 600C>A; p.Ile200Ile	Exon 3	0.02	1.0

aReference sequences: NM_004417 and NP_004408. MAF: minor allele frequency; HWE: Hardy-Weinberg equilibrium.