DUSP1 Gene Polymorphisms Are Associated with Obesity-Related Metabolic Complications among Severely Obese Patients and Impact on Gene Methylation and Expression

Table 4

Genotype differences identified between fasting glucose, lipid profile, and DUSP1 gene variations.

rs13184134

rs7702178

rs881150

Phenotypes

Means^a

P values^b

Means^a

P values^b

Means^a

P values^b

Common HMZ

HTZ

Rare HMZ

Common HMZ

HTZ

Rare HMZ

Common HMZ

HTZ

Rare HMZ

Fasting glucose (mM)

6.48±2.20

6.62±2.52

7.36±3.23

0.04

6.51±2.24

6.61±2.49

7.26±3.20

0.01

6.60±2.35

6.46±2.34

6.63±2.46

0.99

Lipid profile

Total-C (mM)

4.68±0.95

4.67±0.95

4.51±1.00

0.67

4.67±0.95

4.67±0.96

4.49±1.03

0.33

4.65±0.95

4.72±0.92

4.61±1.10

0.81

LDL-C (mM)

2.66±0.82

2.67±0.84

2.51±0.86

0.63

2.65±0.82

2.66±0.85

2.50±0.88

0.22

2.63±0.84

2.71±0.79

2.62±0.94

0.51

HDL-C (mM)

1.23±0.37

1.24±0.32

1.24±0.29

0.39

1.23±0.37

1.25±0.33

1.25±0.30

0.44

1.25±0.35

1.23±0.35

1.18±0.34

0.01

TG (mM)

1.84±1.16

1.77±0.86

1.80±0.85

0.95

1.84±1.16

1.76±0.86

1.79±0.89

0.98

1.81±1.07

1.80±0.98

1.91±1.48

0.93

Total-C/HDL-C

4.05±1.34

3.98±118

3.76±0.96

0.32

4.04±1.35

3.94±1.18

3.73±0.97

0.36

3.94±1.17

4.10±1.46

4.14±1.32

0.07

Blood pressure

SBP (mm Hg)

138.7±17.0

137.6±16.0

136.1±18.7

0.46

138.5±16.9

137.9±16.1

134.4±17.9

0.38

138.3±17.2

138.7±16.2

137.4±17.9

0.65

DBP (mm Hg)

83.4±11.3

83.6±10.9

81.3±11.1

0.42

83.4±11.3

83.7±11.0

80.5±11.8

0.25

83.3±11.3

83.8±11.0

82.7±11.9

0.70

Boldface values represent statistically significant results (𝑃≤0.05).
aValues presented (means ± SD) are untransformed and unadjusted.
bP values obtained are adjusted for the effect of age, sex, and BMI.
HMZ: homozygote; HTZ: heterozygote; Total-C: total cholesterol; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; TG: triglycerides; SBP: systolic blood pressure; DBP: diastolic blood pressure.