Research Article

A Mechanistic, Stochastic Model Helps Understand Multiple Sclerosis Course and Pathogenesis

Figure 4

Histograms of the time duration of relapses and remissions for the 70 selected patients. (a) Histogram of no health events (+1 states); (b) histogram of health events (−1 states). Both figures show exponential decaying distributions with no sign of periodicity (i.e., peak at given duration), suggesting that disease events occur randomly in time. To be noted is the different duration of relapses and remissions (on average 4.3 weeks against about 100 weeks).
910321.fig.004a
(a)
910321.fig.004b
(b)