A Mechanistic, Stochastic Model Helps Understand Multiple Sclerosis Course and Pathogenesis
Figure 8
Potential for three sample patients. As an example, the three patients in Figure 2 are considered (no. 23, no. 32 and no. 53 in our dataset) and the mean duration of their relapses and remissions estimated. These values are then used to compute the ratio of the potential barriers according to (7) (for the estimates see Model Solutions). The potential for each patient ((a)–(c)) is given by (3) setting = 1 and choosing β so that the two wells are asymmetric in the predetermined ratio. In particular, it is found (a) β = 0.25, (b) β = 0.19, and (c) β = 0.12. Dashed line denotes the upper bound of the potential barriers.
