A Promoter Region Polymorphism in PDCD-1 Gene Is Associated with Risk of Rheumatoid Arthritis in the Han Chinese Population of Southeastern China
Figure 2
Increased basal programmed death 1 (PD-1) expression on activated CD4+ T cells in RA patients. (a) A representative flow cytometry analysis of PD-1 expression on CD4+ T cells in RA patients and healthy controls is shown. (b) Upregulated expression of PD-1 on CD4+CD25+, CD4+CD69+, and CD4+HLA-DR+ T cells from RA patients, as compared with those from healthy controls. (c) RA patients homozygous for the rs36084323 SNP (G/G) have significantly increased percentages of PD-1+activated CD4+CD25+, CD4+CD69+, and CD4+HLA-DR+ T cells compared with healthy controls and rs36084323 A/A RA patients (* = , ** = by Mann-Whitney test). Horizontal bars indicate the mean ± SD.
