Research Article
A Promoter Region Polymorphism in PDCD-1 Gene Is Associated with Risk of Rheumatoid Arthritis in the Han Chinese Population of Southeastern China
Table 2
The 4 SNPs of
PDCD-1 gene investigated in the cases (
) and controls (
).
| | SNP | dbSNP ID and position | | Frequency (%) | HWE | | | Allele | | Genotype | | |
| | 1 | rs36084323 | | A | G | | A/A | A/G | G/G | | | | | promoter (−606A/G) | Cases | 47.2 | 52.8 | | 24.7 | 45.1 | 30.3 | | | | | | Controls | 54.1 | 45.9 | 0.014* | 31.1 | 46.5 | 22.5 | 0.049* | 0.12 |
| | 2 | rs11568821 | | A | G | | A/A | A/G | G/G | | | | | Intron 4 (+7146A/G) | Cases | — | 100 | | — | — | 100 | | | | | | Controls | — | 100 | | — | — | 100 | — | — |
| | 3 | rs2227982 | | C | T | | C/C | C/T | T/T | | | | | Eoxn 5 (+7625G/A) | Cases | 51.5 | 48.5 | | 24.8 | 53.5 | 21.8 | | | | | | Controls | 52.5 | 47.5 | 0.74 | 29.6 | 45.8 | 24.6 | 0.19 | 0.21 |
| | 4 | rs2227981 | | C | T | | C/C | C/T | T/T | | | | | Exon 5 (+7786G/C) | Cases | 73.2 | 26.8 | | 54.8 | 36.8 | 8.4 | | | | | | Controls | 68.0 | 32.0 | 0.06 | 47.0 | 42.2 | 10.9 | 0.18 | 0.65 |
|
|
HWE indicates Hardy-Weinberg equilibrium; .
|
