Molecular Evolution of the Vertebrate FK506 Binding Protein 25

Table 1

Site-specific tests for positive selectionof FKBP25.

Species	Models	Estimates of parameters	lnL	2Δ𝑙	Positively selected sites
Vertebrate	M7	𝑝=0.91900  𝑞=8.19764	−5463.938465	0.003806	NA
	M8	𝑝0=0.99999  𝑝=0.91899𝑞=8.19758	−5463.940368		None
		(𝑝1=0.00001)  𝑤=1.86072
Mammalian	M7	𝑝=0.33823𝑞=1.62046	−2182.244789	0.000258	NA
	M8	𝑝0=0.99999𝑝=0.33824𝑞=1.62055	−2182.244918		None
		(𝑝1=0.00001)  𝑤=1.00000
Primate	M7	𝑝=4.13016𝑞=99.00000	−997.077389	0.000102	NA
	M8	𝑝0=0.99999   𝑝=4.12942𝑞=99.00000	−997.077440		None
		(𝑝1=0.00001)  𝑤=1.00000
Mammalian excluding primate	M7	𝑝=0.28229𝑞=1.41420	−2242.306222	0.000160	NA
	M8	𝑝0=0.99999𝑝=0.28230𝑞=1.41430	−2242.306302		NS
		(𝑝1=0.00001)  𝑤=1.00000
Rodent	M7	𝑝=0.13287𝑞=1.19752	−1372.902164	0.000058	NA
	M8	𝑝0=0.99999𝑝=0.13287𝑞=1.19764	−1372.902193		NS
		(𝑝1=0.00001)  𝑤=1.00000
Teleost	M7	𝑝=0.38691𝑞=4.30540	−2354.923181	0.000408	NA
	M8	𝑝0=0.99999𝑝=0.38690𝑞=4.30545	−2354.923385		NS
		(𝑝1=0.00001)  𝑤=3.90806

lnL: the log-likelihood difference between the two models; 2Δ𝑙: twice the log-likelihood difference between the two models (In all the species, 2Δ𝑙<9.21, the 𝑃-value is more than the significance level 0.05, indicating that M8 model is not better than M7 model); NA: not allowed; NS: not shown (it means the sites under positive selection but not reaching the significance level of 0.9).