Research Article
Genetic Variations of Cytokines and Cytokine Receptors in Psoriasis Patients from China
Table 2
Genotyping of seven studied SNPs in psoriasis patients (
) and controls (
).
| | SNP | Gene | Population | Genotype (%) | Minor allele (%) |
| | rs2243250 | IL4 | | T/T | T/C | C/C | C | | Controls | 189 (63.4) | 98 (32.9) | 11 (3.7) | 120 (20.1) | | Psoriasis | 127 (63.5) | 61 (30.5) | 12 (6.0) | 85 (21.3) |
| | rs1800872 | IL10 | | A/A | A/C | C/C | C | | Controls | 138 (46.3) | 123 (41.3) | 37 (12.4) | 197 (33.1) | | Psoriasis | 93 (46.5) | 86 (43.0) | 21 (10.5) | 128 (32.0) |
| | rs3212227 | IL12B | | A/A | A/C | C/C | C | | Controls | 119 (39.9) | 128 (43.0) | 51 (17.1) | 230 (38.6) | | Psoriasis | 77 (38.5) | 104 (52.0) | 19 (9.5)*a | 142 (35.5) |
| | rs1800925 | IL13 | | C/C | C/T | T/T | T | | Controls | 222 (74.5) | 72 (24.2) | 4 (1.3) | 80 (13.4) | | Psoriasis | 140 (70.0) | 52 (26.0) | 8 (4.0) | 68 (17.0) |
| | rs20541 | IL13 | | C/C | C/T | T/T | T | | Controls | 146 (49.0) | 126 (42.3) | 26 (8.7) | 178 (29.9) | | Psoriasis | 100 (50.0) | 80 (40.0) | 20 (10.0) | 120 (30.0) |
| | rs56245420 | IL15 | | A/A | A/T | T/T | T | | Controls | 139 (46.6) | 135 (45.3) | 24 (8.1) | 183 (30.7) | | Psoriasis | 78 (39.0) | 97 (48.5) | 25 (12.5) | 147 (36.8) |
| | rs11209026 | IL23R | | G/G | G/A | A/A | A | | Controls | 298 (100) | 0 | 0 | 0 | | Psoriasis | 200 (100) | 0 | 0 | 0 |
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