Helicobacter pylori: Genomic Insight into the Host-Pathogen Interaction

Figure 3

Model of H. pylori-host interaction in vivo. (A) H. pylori encounters numerous ions in the gastric niche and utilizes flagella to penetrate the mucus layer and reach the gastric epithelia. (B) H. pylori secretes VacA and CagA cytotoxins, causing changes in host cell biology. (C) The adaptive immune response as a consequence of H. pylori infection is skewed to expand Th1 and Th17 populations.