Differential Analysis of Genetic, Epigenetic, and Cytogenetic Abnormalities in AML

Figure 4

Hierarchical clustering of AML samples. Heatmap displayed only sites with the highest variance across all samples and complete linkage strategy. x-axis represents the number of patients, and y-axis represents different CpG regions. Gray color in across x-axis side bar represents unknown for particular trait. Color key represents beta value (red means hypomethylated and blue means hypermethylated). Del (5q)-positive patients show mostly hypermethylation across the genomic regions. T (15; 17)-positive patients show hypomethylation across the genomic regions.