| | Cancer type | | Number of genes | Disease |
| | BRCA | hsa-mir-1269 | 381 | Lung cancer, colorectal cancer, hepatocellular carcinoma | | hsa-mir-934 | 368 | — | | hsa-mir-2115 | 325 | — | | hsa-mir-618 | 305 | — | | hsa-mir-1251 | 286 | — | | hsa-mir-9-3 | 282 | Breast neoplasms, stomach neoplasms, glioblastoma | | hsa-mir-105-2 | 268 | Biliary tract neoplasms, hepatocellular carcinoma | | hsa-mir-767 | 268 | Melanoma, rhinitis, allergy, perennial | | hsa-mir-449a | 264 | Breast cancer, adenocarcinoma, colonic neoplasms, ovarian neoplasms | | hsa-mir-885 | 261 | Leukemia | | hsa-mir-105-1 | 253 | Biliary tract neoplasms, hepatocellular carcinoma | | hsa-mir-135a-1 | 251 | Breast neoplasms, colorectal neoplasms, non-small-cell lung carcinoma | | hsa-mir-3662 | 246 | Gastric cancer, head and neck cancer | | hsa-mir-138-1 | 242 | Oral squamous cell carcinoma, renal cell carcinoma, urinary bladder neoplasms | | hsa-mir-376a-2 | 234 | Adrenocortical carcinoma, glioblastoma, lung neoplasms | | hsa-mir-137 | 233 | Breast neoplasms, malignant melanoma, glioblastoma multiforme | | hsa-mir-3190 | 232 | — | | hsa-mir-138-2 | 231 | Papillary thyroid carcinoma, oral squamous cell carcinoma, pituitary adenoma | | hsa-mir-372 | 231 | Colorectal cancer, acute myeloid leukemia, stomach neoplasms | | hsa-mir-3926-2 | 231 | — |
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