A New Network-Based Strategy for Predicting the Potential miRNA-mRNA Interactions in Tumorigenesis

Table 5

The top 5 GO terms enriched with the genes connected with the cancer-specific miRNAs.

Cancer type	Category	Term	value
AML	GOTERM_BP_4	GO:0009887 ~ organ morphogenesis
		GO:0048705 ~ skeletal system morphogenesis
		GO:0001501 ~ skeletal system development
		GO:0003002 ~ regionalization
		GO:0048704 ~ embryonic skeletal system morphogenesis
	GOTERM_MF_4	GO:0043565 ~ sequence-specific DNA binding	0.0055
		GO:0003700 ~ transcription factor activity	0.0075
		GO:0008236 ~ serine-type peptidase activity	0.0286
		GO:0004888 ~ transmembrane receptor activity	0.0301
BRCA	GOTERM_BP_4	GO:0019226 ~ transmission of nerve impulse
		GO:0007268 ~ synaptic transmission
		GO:0007417 ~ central nervous system development
		GO:0044057 ~ regulation of system process
		GO:0009888 ~ tissue development
	GOTERM_MF_4	GO:0030594 ~ neurotransmitter receptor activity
		GO:0015267 ~ channel activity
		GO:0015075 ~ ion transmembrane transporter activity
		GO:0008188 ~ neuropeptide receptor activity
		GO:0005179 ~ hormone activity
KIRC	GOTERM_BP_4	GO:0006954 ~ inflammatory response
		GO:0007186 ~ G protein-coupled receptor signaling pathway
		GO:0050707 ~ regulation of cytokine secretion
		GO:0050663 ~ cytokine secretion	0.0002
		GO:0050715 ~ positive regulation of cytokine secretion	0.0003
	GOTERM_MF_4	GO:0005125 ~ cytokine activity	0.0002
		GO:0004930 ~ G protein-coupled receptor activity	0.0002
		GO:0001664 ~ G protein-coupled receptor binding	0.0004
		GO:0005126 ~ cytokine receptor binding	0.0007
		GO:0004984 ~ olfactory receptor activity	0.0013

The Go term was directly associated with the corresponding cancer type. The Go term was associated with other cancers.