Serum and Brain Metabolomic Variations Reveal Perturbation of Sleep Deprivation on Rats and Ameliorate Effect of Total Ginsenoside Treatment

Table 4

Differential expressed cerebral metabolites.

Class	Brain metabolites	M/WP		GS/M		GS/WP
		value	log2	value	log2	value	log2
Type 1	Citric acid	1.30E−03	0.15	1.60E−04	−0.23	1.32E−01	−0.08
	Glycerol 2-phosphate	3.01E−03	0.18	2.21E−02	−0.12	2.69E−01	0.05
	Cytidine monophosphate	1.26E−03	0.27	8.06E−03	−0.29	8.30E−01	−0.02
	Inositol	7.45E−07	0.28	2.11E−02	−0.11	2.63E−03	0.17
Type 2	Glucose 6-phosphate	6.86E−03	−1.13	6.64E−03	1.03	7.54E−01	−0.10
	Fructose 6-phosphate	9.04E−04	−0.99	4.18E−03	0.62	9.80E−02	−0.37
	Sedoheptulose 7-phosphate	6.06E−03	−0.89	5.09E−02	0.48	1.05E−01	−0.41
	Dihydroxyacetone phosphate	1.06E−02	−0.63	9.45E−02	0.33	1.37E−01	−0.29
	Ribose	1.83E−07	−0.50	1.06E−03	0.19	1.54E−04	−0.31
	Malic acid	1.31E−03	−0.13	1.25E−03	0.11	5.07E−01	−0.02
	Hypoxanthine	3.47E−03	−0.24	1.82E−02	0.12	1.02E−01	−0.12
	Xanthine	2.52E−03	−0.40	3.05E−02	0.14	2.56E−02	−0.27
	Uracil	2.65E−02	−0.14	4.24E−03	0.16	7.26E−01	0.02
	Inosine	2.89E−02	−0.20	2.44E−01	0.10	3.04E−01	−0.10
	Valine	3.77E−03	−0.16	4.37E−05	0.23	2.68E−02	0.07
	Leucine	2.82E−05	−0.20	1.43E−05	0.18	6.53E−01	−0.02
	Isoleucine	3.17E−05	−0.20	1.37E−04	0.18	6.34E−01	−0.02
	Cysteine	5.07E−03	−0.26	1.05E−03	0.27	8.60E−01	0.01
	Palmitoleic acid	2.63E−02	−0.27	3.25E−01	0.11	1.28E−01	−0.16
Type 3	Threonic acid	4.46E−03	−0.21	1.98E−02	−0.19	1.34E−06	−0.40
	4-Hydroxyproline	1.26E−05	−0.37	5.77E−03	−0.19	2.48E−08	−0.56
Type 4	Threonine	2.82E−09	−0.32	1.36E−01	−0.04	1.31E−11	−0.37
	Serine	8.57E−04	−0.13	4.13E−01	−0.03	2.34E−04	−0.16
	Methionine	2.65E−06	−0.37	6.25E−01	−0.02	1.28E−06	−0.39
	Fructose	1.75E−04	−0.26	7.91E−01	−0.01	1.63E−05	−0.28
	Pantothenic acid	3.87E−04	−0.23	6.90E−01	0.03	7.00E−03	−0.20
	Lactic acid	5.96E−03	−0.11	4.31E−01	−0.03	6.51E−04	−0.14
	Sedoheptulose	5.90E−07	−0.63	6.64E−02	0.13	3.57E−06	−0.49
	Ribulose 5-phosphate	6.18E−04	−0.70	2.30E−01	0.22	2.59E−03	−0.48
	Pyruvic acid	7.10E−05	−0.70	5.68E−01	0.08	3.45E−05	−0.62
	Tyrosine	8.13E−03	−0.48	9.04E−01	0.02	1.65E−02	−0.46
Type 5	Aspartic acid	3.65E−02	0.07	3.47E−01	−0.03	2.19E−01	0.04
	Glutamic acid	4.55E−02	0.10	6.97E−01	−0.02	6.84E−02	0.08
	Glycerol 3-phosphate	1.23E−05	0.60	3.31E−01	−0.07	1.98E−06	0.53
	Ribose 5-phosphate	2.35E−02	0.22	7.91E−01	0.03	3.16E−02	0.25
	Adenosine	4.42E−05	0.78	2.88E−01	0.22	8.52E−04	1.01
Type 6	Succinic acid	6.32E−06	0.96	9.93E−04	0.43	1.04E−09	1.39
	2-Aminobutyric acid	7.27E−03	0.29	5.91E−06	0.52	6.26E−11	0.81
	3-Hydroxybutyric acid	7.96E−06	0.30	1.39E−08	0.55	1.98E−11	0.85