Biological Function of MicroRNA193a-3p in Health and Disease

Figure 1

Genomic location of miR-193a coding sequence, stem-loop hairpin structure of pre-miR-193a and miR-193a-3p/miR-193a-5p sequences. (a) The analysis of the genomic region coding miR-193a referred to Genome Browser (https://genome-euro.ucsc.edu/). MIR193a coding sequence is located on human chromosome 17q11.2 characterized by a typical CpG island (in green). The layered H3K27Ac, H3K4Me1, and H3K4Me3 show the levels of histone marks across the genome in 7 cell lines (data obtain from ENCODE on the basis of ChiP-seq assay). By default, this track displays data from a number of cell lines in the same vertical space and each of the cell line is associated with a particular color. The regulatory element (in orange) is described as transcription factor binding sites by ORegAnno (open regulatory annotation). (b) The MIR193a gene is transcribed into a precursor (pre-miR-193a) with 88 nucleotides that is processed during miRNA biogenesis to yield mature miR-193a-5p (in red) and mature miR-193a-3p (in green) with 22 nucleotides in length.