Review Article
Biological Function of MicroRNA193a-3p in Health and Disease
Table 1
Regulation of miR-193a-3p expression by different mechanisms.
| Mechanisms of regulation | Effect on miR-193a-3p expression | Sample type | Experimental procedures | Ref. |
| Transcription factors: | | | | | Max and RXRα | Downregulation | Transformed breast epithelial cells | ChIP; siRNA-mediated inhibition experiments | [3] | AML1/ETO | Downregulation | AML cell lines primary AML samples with t(8;12) | Luciferase reporter assay; ChIP | [4] | HNF4α | Upregulation | Liver from mice with liver-specific knockout of HNF4α | miRNA microarray and qPCR in Hnf4α-LivKO mice | [5] | DNA methylation: | | | | | DNA hypermethylation | Downregulation | AML cell lines AML primary samples | MSP Bisulfite sequencing | [9] | DNA hypermethylation | Downregulation | OSC carcinoma cells and primary AML samples | COBRA Bisulfite sequencing | [8] | DNA hypermethylation | Downregulation | NSCL cancer cells NSCL specimens | MSP Bisulfite sequencing | [10, 11] | DNA hypermethylation | Downregulation | Highly metastatic osteosarcoma cells | Bisulfite sequencing | [12] | DNA hypomethylation | No effect | HCC cell lines HCC specimens | MSP | [14] | DNA hypomethylation | No effect | Mesothelioma | MSP | [13] | Regulatory protein: | | | | | XB130 | Downregulation | Thyroid carcinoma cells | shNA-mediated inhibition and ectopic expression experiments | [7] | Competing endogenous RNA (ceRNA) network: | | | | | Linc00152 | Downregulation | Colon cancer cells | RIP; luciferase reporter assay | [17] | LncRNA-UCA1 | Downregulation | NSCL cells | RIP; luciferase reporter assay | [18] |
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