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Target genes | Functions | Cell line | References |
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K-Ras | Oncogene involved in many functions: antiapoptotic activity, angiogenesis, motility, cell growth | Breast cancer Lung cancer | [3, 29] |
PLAU | Promotes cancer invasion and metastasis; the interaction of uPA with its receptor induced also cell proliferation, migration, and expression of specific genes | Transformed breast epithelial cells Breast cancer HCC BCa | [3, 32, 33, 40] |
Mcl-1 | Antiapoptotic gene, member of the Bcl-2 family | HeLa cells Ovarian cancer | [30, 31] |
ERBB4 | Induces a variety of cellular responses including mitogenesis and differentiation; triggers proliferation, invasion, and migration | Lung cancer NSCLC | [27, 37] |
S6 K2 | Promote cell survival | NSCLC | [37] |
PepT1 | Transporter involved in the low uptake of small bacterial peptides in a normal colon and of dietary proteins | Epithelial colorectal adenocarcinoma | [46] |
c-kit | Oncogene. Activates many pathways involved in proliferation, differentiation, migration, and survival | AML | [9] |
Aml1/Eto | Chimeric protein associated with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation | AML | [4] |
HDAC3 | Regulates transcription and modulates cell growth an apoptosis | AML | [4] |
DNMT3a | De novo DNA methylation | AML | [4] |
Cyclin D1 | Cell cycle progression | AML Breast cancer | [4] [28] |
E2F6 | Transcription factor with a main role in the control of the cell cycle | OSCC | [8] |
Rab27B | Increased invasion and metastasis in cancer | Osteosarcoma | [12] |
HMGB1 | Tissue repair and regeneration, migration, angiogenesis, endothelial recruitment, and proliferation | Endothelial colony forming cell, ECFC | [21] |
HYOU-1 | Cytoprotective role in hypoxia-induced cellular perturbation | Endothelial colony-forming cell, ECFC | [21] |
PSEN1 | Promote cell proliferation | Esophageal squamous cell carcinoma Bladder cancer | [45] |
E2F1 | Transcription factor; control of the cell cycle and apoptosis | HCC | [15] |
SRSF2 | Regulates constitutive and alternative splicing; induces proapoptotic splice forms of apoptotic genes | HCC | [15] |
HIC2 | Putative transcriptional factor | BCa | [40] |
HOXC9 | Transcription factor; role in morphogenesis | BCa | [43] |
ING5 | Inhibit cell growth and induce apoptosis | BCa | [42] |
LOXL4 | Biogenesis of connective tissue: catalyzes the first step in the formation of crosslinks in collagens and elastin | BCa | [41] |
SLC7A5 | Large neutral amino acid transporter small subunit 1 | Thyroid carcinoma | [7] |
JNK1 | MAP kinases involved in proliferation, differentiation, transcription regulation, and development | Breast cancer | [26] |
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