International Journal of Genomics

Review Article

Circular RNAs: Biogenesis, Function, and a Role as Possible Cancer Biomarkers

Table 2

CircRNAs associated with cancer.


CircRNA	Gene symbol	Cancer type	Expression	Fold change^a	Function	References

CiRS-7/CDR1as	CDR1	HCC	Up	NA	Sponge: miR-7	[91]
		HCC	Down^b	NA	Sponge: miR-7	[137]
		Colorectal	Up	NA	Sponge: miR-7	[92]
		Colorectal	Up	2.4	Sponge: miR-7	[132]
		GBM	Down	3.5	Target of miR-671-5p Association with cell proliferation and migration	[94]
Circ-Foxo3	FOXO3	Breast	Down	NA	Sponge: miR-22, miR-136, miR-138, miR-149, miR-433, miR-762, miR-3614-5p, miR-3622b-5p Association with apoptosis-related proteins Foxo3, MDM2, p53, and Puma and cell cycle proteins CDK2 and p21	[95–97]
Circ-ABCB10	ABCB10	Breast	Up	5.0–10.0	Sponge: miR-1271	[98]
Hsa_circ_001569	ABCC1	Colorectal	Up	NA	Sponge: miR-145	[99]
		HCC	Up	NA	Promoting tumor growth	[100]
CircHIPK3	HIPK3	HCC	Up	NA	Sponge: miR-124	[101]
		Bladder	Down	4.6	Sponge: miR-558	[103]
Cir-ITCH	ITCH	ESCC	Down	NA	Sponge: miR-7, miR-17, miR-214 Inhibition of the Wnt/β-catenin pathway	[104]
		Colorectal	Down	NA	Sponge: miR-7, miR-20a Inhibition of the Wnt/β-catenin pathway	[105]
		Lung	Down	NA	Sponge: miR-7, miR-214 Inhibition of the Wnt/β-catenin pathway	[106]
Hsa_circ_0067934	PRKCI	ESCC	Up	8.8	Promoting cell proliferation and migration	[107]
Circ-ZEB1.5	ZEB1	Lung	Down	NA	Sponge: miR-200a-3p	[58]
Circ-ZEB1.19
Circ-ZEB1.17
Circ-ZEB1.33
CircMYLK	MYLK	Bladder	Up	NA	Sponge: miR-29a-3p	[109]
CircRNA_100290	SLC30A7	OSCC	Up	6.9	Sponge: miR-29 family	[110]
Hsa_circ_0016347	KCNH1	Osteosarcoma	Up	NA	Sponge: miR-214	[111]
Hsa_circ_0001564	CANX	Osteosarcoma	Up	NA	Sponge: miR-29c-3p	[114]
CircRNA_100269	LPHN2	Gastric	Down	NA	Sponge: miR-630	[116]
Hsa_circ_0020397	DOCK1	Colorectal	Up	NA	Sponge: miR-138	[117]
Hsa_circ_0000069	STIL	Colorectal	Up	≥1.0	Promoting cell proliferation, invasion, and migration	[118]
Circ-TTBK2	TTBK2	Glioma	Up	NA	Sponge: miR-217	[121]
cZNF292	ZNF292	Glioma	Up	NA	Promoting cell proliferation and tube formation	[122]
f-circRNA	PML/RARα^c	APL	Up	NA	Promoting cell proliferation, transformation, and tumorigenesis	[123]
CircTCF25	TCF25	Bladder	Up	21.4	Sponge: miR-103a-3p, miR-107	[129]
Hsa_circ_001988	FBXW7	Colorectal	Down	NA	ND	[130]
Hsa_circRNA_103809	ZFR	Colorectal	Down	3.6	Sponge: miR-511-5p, miR-130b-5p, miR-642a-5p, miR-532-3p, miR-329-5p	[131]
Hsa_circRNA_104700	PTK2	Colorectal	Down	4.2	Sponge: miR-141-5p, miR-500a-5p, miR-509-3p, miR-619-3p, miR-578	[131]
CircRNA_100876	RNF121	NSCLC	Up	1.2	Sponge: miR-136	[133]
Hsa_circ_0001649	SHPRH	HCC	Down	NA	Sponge: miR-1283, miR-4310, miR-182-3p, miR-888-3p, miR-4502, miR-6811, miR-6511b-5p, miR-1972 Promoting metastasis	[127]
		Gastric	Down	NA	ND	[141]
Hsa_circ_0005075	EIF4G3	HCC	Up	NA	Sponge: miR-23b-5p, miR-93-3p, miR-581, miR-23a-5p Promoting cell adhesion	[128]
CircZKSCAN1	ZKSCAN1	HCC	Down	NA	Inhibition of cellular growth, migration, and invasion	[138]
Hsa_circ_0005986	PRDM2	HCC	Down	2.9	Sponge: miR-129-5p	[139]
Hsa_circ_0004018	SMYD4	HCC	Down	NA	Sponge: miR-30e-5p, miR-647, miR-92a-5p, miR-660-3p, miR-626	[140]
Hsa_circ_002059	KIAA0907	Gastric	Down	NA	ND	[16]
Hsa_circ_0000096	HIAT1	Gastric	Down	NA	Sponge: miR-224, miR-200a Inhibition of cell growth and migration	[142]
Hsa_circ_0001895	PRRC2B	Gastric	Down	NA	ND	[143]
Hsa_circ_0006633	FGGY	Gastric	Down	NA	ND	[144]
Hsa_circ_0000190	CNIH4	Gastric	Down	NA	ND	[145]
Hsa_circ_0003159	CACNA2D1	Gastric	Down	NA	ND	[146]
CircPVT1	PVT1	Gastric	Up	NA	Sponge: miR-125 family Promoting cell proliferation	[148]
Hsa_circ_100855	C11orf80	LSCC	Up	10.5	ND	[150]
Hsa_circ_104912	DENND1A	LSCC	Down	4.7	ND	[150]

HCC: hepatocellular carcinoma; GBM: glioblastoma multiforme; ESCC: esophageal squamous cell carcinoma; OSCC: oral squamous cell carcinoma; APL: acute promyelocytic leukemia; NSCLC: non-small-cell lung cancer; LSCC: laryngeal squamous cell cancer. Up: upregulated; down: downregulated. NA: not available (data is presented in a graphical format in the original report). ND: not determined. Potential cancer biomarker. ^aFold change values, relative to normal controls. ^bExpression levels were not statistically significant. ^cOne or more f-circRNAs were generated from PML/RARα fusion gene, a product of the most recurrent cancer-associated aberrant chromosomal translocation in APL. In addition, other chromosomal translocations may also generate f-circRNAs.