Research Article
An Exploration of Gene-Gene Interactions and Their Effects on Hypertension
Table 2
Genotype counts for SNP pairs and odds ratios relative to the double major allele homozygote genotype in the offspring sample.
(a) |
| | | rs9489622 | rs4235144 | GG | GA | AA |
| Controls | CC | 0 | 0 | 0 | CT | 0 | 18 | 14 | TT | 278 | 550 | 292 | Hypertension | CC | 0 | 0 | 0 | CT | 17 | 7 | 1 | TT | 262 | 556 | 315 | ORa relative to TT/AA (95% CI) | CC | — | — | — | CT | — | 0.36 (0.148–0.876) | 0.07 (0.009–0.507) | TT | 0.87 (0.693–1.102) | 0.94 (0.769–1.142) | 1 |
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(b) |
| | | rs3913226 | rs2058798 | TT | TC | CC |
| Controls | AA | 0 | 0 | 0 | AG | 2 | 19 | 1 | GG | 25 | 310 | 781 | Hypertension | AA | 0 | 0 | 0 | AG | 0 | 5 | 27 | GG | 30 | 332 | 745 | ORa relative to GG/CC (95% CI) | AA | — | — | — | AG | 0.21 (0.010–4.375) | 0.28 (0.103–0.743) | 28.30 (3.836–208.829) | GG | 1.26 (0.733–2.159) | 1.12 (0.934–1.350) | 1 |
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(c) |
| | | rs17284390 | rs1909884 | GG | GA | AA |
| Controls | AA | 2 | 24 | 132 | AG | 8 | 117 | 398 | GG | 15 | 108 | 351 | Hypertension | AA | 7 | 46 | 82 | AG | 15 | 110 | 428 | GG | 0 | 76 | 391 | ORa relative to GG/AA (95% CI) | AA | 3.14 (0.648–15.225) | 1.72 (1.029–2.877) | 0.56 (0.409–0.761) | AG | 1.68 (0.705–4.018) | 0.84 (0.627–1.137) | 0.97 (0.792–1.177) | GG | 0.03 (0.002–0.486) | 0.63 (0.456–0.876) | 1 |
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(d) |
| | | rs12484954 | rs17688362 | CC | CG | GG |
| Controls | TT | 3 | 40 | 8 | TG | 60 | 198 | 121 | GG | 88 | 325 | 307 | Hypertension | TT | 12 | 9 | 26 | TG | 57 | 160 | 149 | GG | 109 | 363 | 257 | ORa relative to GG/GG (95% CI) | TT | 4.78 (1.334–17.117) | 0.27 (0.128–0.564) | 3.88 (1.728–8.723) | TG | 1.13 (0.762–1.691) | 0.97 (0.740–1.260) | 1.47 (1.099–1.969) | GG | 1.48 (1.068–2.050) | 1.33 (1.067–1.668) | 1 |
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Note. . aOR is odds ratio.
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