Uncover the Underlying Mechanism of Drug-Induced Myopathy by Using Systems Biology Approaches

Figure 1

Flowchart of the study: (1) similarity between DIM drugs based on chemical similarity and protein distance in PPI network; (2) myopathy-related side effects based on Fisher’s exact test and network analysis; (3) the DIM transcriptomic analysis based on CMap data; (4) structure alert of DIM.