Uncover the Underlying Mechanism of Drug-Induced Myopathy by Using Systems Biology Approaches
Table 1
Selected examples of myopathy and associated side effects by literature survey.
Myopathy-associated side effects
value by Fisher’s exact test
Notes
References
Diabetes mellitus
1.00E−11
In any diabetic condition, a failure to maintain healthy muscle is often observed and is termed diabetic myopathy
PMID: 24391596
Rhabdomyolysis
<1.00E−15
Rhabdomyolysis is a severe form of myopathy
PMID: 25991405
Creatine phosphokinase increased
7.00E−11
Increased dosage of cyclosporine induces myopathy with increased serum creatine kinase in an elderly patient on chronic statin therapy
PMID: 25512016
Neuropathy
<1.00E−15
Critically ill patients may develop muscle weakness or paralysis such as neuropathy during the course of sepsis and multiple organ failure
PMID: 15758592
Alkalosis hypokalaemia
6.11E−09
A case report about hypokalemia-induced myopathy as the first manifestation of primary hyperaldosteronism due to unilateral adrenal hyperplasia
PMID: 19829865
Rheumatoid arthritis
9.69E−09
Based on 86 patients with verified rheumatoid arthritis, 5.8% patients were found with peripheral myopathy
PMID: 13917616
Osteoporosis
3.90E−10
Chronic use of glucocorticoids (GCs) is the most common cause of secondary osteoporosis. The glucocorticoids induce myopathy as well
PMID: 22870429
Hepatic steatosis
7.20E−10
A case report showed that zidovudine treatment can induce mitochondrial multisystem disease, as revealed in our case by myopathy, liver steatosis, and lactic acidosis
PMID: 9927163
Cardiomegaly
1.60E−10
Two unrelated 16-year-old boys had mental retardation, cardiomegaly, and proximal myopathy
