Gene Variation of Endoplasmic Reticulum Aminopeptidases 1 and 2, and Risk of Blood Pressure Progression and Incident Hypertension among 17,255 Initially Healthy Women
Table 2
Logistic regression analysis for all SNPs evaluated with blood pressure progression.
dbSNP
MA
MAF
OR
Lower 95% CI
Upper 95% CI
-uncorrected
ERAP1
rs1559085
G
0.1413
1.056
0.988
1.129
0.1094
rs27851
G
0.0607
0.946
0.858
1.043
0.2686
rs3756623
C
0.0750
0.970
0.888
1.059
0.4924
rs754615
C
0.3907
1.014
0.967
1.064
0.5581
rs1862609
A
0.3129
1.022
0.973
1.075
0.3846
rs27772
G
0.3133
0.948
0.901
0.997
0.0366
rs28081
A
0.1510
1.006
0.943
1.073
0.8643
rs27037
A
0.2957
1.040
0.988
1.094
0.1314
rs27429
C
0.0598
0.943
0.855
1.041
0.2457
rs27524
A
0.3730
1.036
0.987
1.087
0.1497
rs25862
A
0.4488
0.996
0.951
1.044
0.8777
rs11135480
C
0.1321
1.032
0.964
1.105
0.3662
rs10515247
A
0.1323
1.033
0.964
1.106
0.3593
rs149078
A
0.2965
0.975
0.927
1.026
0.3280
rs27042
A
0.3655
0.959
0.914
1.007
0.0913
rs27044
G
0.2795
1.025
0.973
1.079
0.3557
rs17482078
A
0.2039
1.039
0.981
1.101
0.1883
rs42398
G
0.1470
1.009
0.945
1.077
0.7856
rs469783
G
0.4374
1.016
0.970
1.065
0.4956
rs10050860
A
0.2127
1.026
0.969
1.086
0.3862
rs13154629
A
0.2131
1.035
0.978
1.096
0.2276
rs30187
A
0.3478
1.019
0.971
1.070
0.4463
rs27434
A
0.2175
1.003
0.948
1.062
0.9069
rs26618
G
0.2370
0.975
0.923
1.030
0.3650
rs25866
A
0.2341
0.998
0.943
1.055
0.9369
rs26653
C
0.2835
0.984
0.934
1.036
0.5304
rs34753
G
0.2796
0.979
0.930
1.031
0.4259
rs28129
G
0.2804
0.979
0.930
1.031
0.4227
rs18036
G
0.2441
0.982
0.930
1.037
0.5188
rs152280
A
0.2085
0.991
0.936
1.049
0.7572
rs12520537
G
0.1537
0.987
0.926
1.053
0.6997
rs41135
G
0.4669
1.016
0.970
1.064
0.5092
rs34736
A
0.0648
0.929
0.845
1.021
0.1254
ERAP2
rs2911132
A
0.3726
1.014
0.967
1.064
0.5638
rs2042381
A
0.2733
1.022
0.970
1.077
0.4111
rs2927615
A
0.2404
1.027
0.973
1.084
0.3339
rs2927612
G
0.1168
0.993
0.924
1.067
0.8550
rs2549778
A
0.4292
1.005
0.959
1.053
0.8417
rs6861666
G
0.0781
1.014
0.930
1.106
0.7579
rs3733904
G
0.2117
0.965
0.911
1.022
0.2239
rs2549779
G
0.4880
0.983
0.939
1.030
0.4843
rs4869315
A
0.4241
0.969
0.924
1.015
0.1846
rs2549782
C
0.4093
1.047
0.999
1.097
0.0569
rs17408150
T
0.0560
1.050
0.948
1.162
0.3470
rs7714122
G
0.0648
0.999
0.908
1.098
0.9794
Adjusted for age, body mass index, history of diabetes, history of hyperlipidemia, current smoking, exercise, alcohol use, education level, current hormone use, and randomized treatment assignment. MA = minor; MAF = minor allele frequency; OR = odds ratio; CI = confidence interval.
