Gene Variation of Endoplasmic Reticulum Aminopeptidases 1 and 2, and Risk of Blood Pressure Progression and Incident Hypertension among 17,255 Initially Healthy Women

Table 4

Summary of association of the GTEx SNP list evaluated with the phenotypic outcomes examined in the present study.

ERAP1	Coronary artery	Tibial artery	Adrenal gland	Left ventricle	B-SBP	B-DBP	Prog	HTN
rs27524	0.0042	0.00087	<0.0001	<0.0001	0.0492	ns	ns	ns
rs27851	0.043	0.0023	0.13	0.66	ns	0.0083	ns	ns
rs27429	0.08	0.0025	0.53	0.55	ns	0.0093	ns	ns
rs30187	0.00022	<0.0001	<0.0001	<0.0001	ns	ns	ns	ns
rs34736	0.10	0.00016	0.23	0.58	ns	0.0175	ns	ns
rs27772	0.052	<0.0001	0.00028	0.18	ns	ns	0.0366	ns
rs469783	0.0042	<0.0001	0.002	0.00075	ns	ns	ns	0.0291
rs10050860	0.88	<0.0001	0.18	0.023	ns	ns	ns	0.0351
ERAP2
rs3733904	<0.0001	<0.0001	0.0029	<0.0001	0.0090	ns	ns	ns
rs4869315	<0.0001	<0.0001	<0.0001	<0.0001	0.0108	ns	ns	ns
rs2549782	<0.0001	<0.0001	<0.0001	<0.0001	0.0320	ns	ns	ns
rs2927615	0.39	0.64	0.75	0.51	ns	ns	ns	0.0107

Values presented are values for gene expression analysis from the GTEx Portal database (GTEx Analysis Release V6p). Values presented are uncorrected values reported in the present investigation. B-SBP = baseline systolic blood pressure; B-DBP = baseline diastolic blood pressure; Prog = blood pressure progression; HTN = incident hypertension; ns =  value >0.05.