Research Article
Additional Evidence for DDB2 T338M as a Genetic Risk Factor for Ocular Squamous Cell Carcinoma in Horses
Table 1
Haflinger samples selected for whole genome sequencing based on phenotype, age, DDB2 c.1013 C>T genotype, and ECA12 haplotype analysis.
| Sample | Status | DDB2 genotype | Age at ocular exam | Features for selection |
| HF-14-62 | Affected limbal SCC | C/C | 13 | Haplotype with majority case minor alleles | HF-14-55 | Affected limbal SCC | C/C | 6 | Haplotype with majority case major alleles | HF-13-25 | Affected limbal SCC | T/T | 9 | Defined 3 breakpoint of haplotype | HF-15-07 | Affected limbal and nictitating membrane SCC | T/T | 12 | Defined 5 breakpoint of haplotype | HF-13-17 | Unaffected | C/C | 27 | Oldest sample at the time of submission | HF-13-33 | Unaffected | T/T | 20 | Risk haplotype |
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