Research and Discussion on the Relationships between Noise-Induced Hearing Loss and ATP2B2 Gene Polymorphism

Table 3

Distribution of three polymorphisms and the association with NIHL.

Genetic models	Genotypes	Case group		Control group		^a	Adjusted OR (95% CI)^b
			%		%
rs1719571
Codominant	AA	141	37.1	161	42.4	0.332	1.00 (ref.)
	AG	183	48.2	167	43.9		1.25 (0.92-1.70)
	GG	56	14.7	52	13.7		1.26 (0.81-1.96)
Dominant	AA	141	37.1	161	42.4	0.138	1.00 (ref.)
	GG+AG	239	62.9	219	57.6		1.25 (0.93-1.67)
Recessive	AG+AA	324	85.3	328	86.3	0.678	1.00 (ref.)
	GG	56	14.7	52	13.7		1.11 (0.74-1.68)
Alleles	A	465	61.2	489	64.3	0.203	1.00 (ref.)
	G	295	38.8	271	35.7		1.15 (0.94-1.42)
rs14154
Codominant	CC	119	31.3	144	37.9	0.129	1.00 (ref.)
	CG	211	55.5	185	48.7		1.39 (1.02-1.90)
	GG	50	13.2	51	13.4		1.21 (0.76-1.92)
Dominant	CC	119	31.3	144	37.9	0.057	1.00 (ref.)
	CG+GG	261	68.7	236	62.1		1.35 (1.00-1.83)
Recessive	CG+CC	330	86.8	329	86.6	0.915	1.00 (ref.)
	GG	50	13.2	51	13.4		0.99 (0.65-1.51)
Alleles	C	449	59.1	473	62.2	0.208	1.00 (ref.)
	G	311	40.9	287	37.8		1.15 (0.94-1.42)
rs3209637
Codominant	TT	83	21.8	92	24.2	0.027	1.00 (ref.)
	CT	203	53.4	224	58.9		1.01 (0.71-1.44)
	CC	94	24.7	64	16.8		1.67 (1.08-2.58)
Dominant	TT	83	21.8	92	24.2	0.438	1.00 (ref.)
	CC+CT	297	78.2	288	75.8		1.15 (0.82-1.62)
Recessive	CT+TT	286	75.3	316	83.2	0.007	1.00 (ref.)
	CC	94	24.7	64	16.8		1.66 (1.16-2.37)
Alleles	T	369	48.6	408	53.7	0.045	1.00 (ref.)
	C	391	51.4	352	46.3		1.24 (1.01-1.52)

^aTwo-sided test. ^bAdjusted for age, sex, tobacco use, and alcohol consumption in the logistic regression model.