Identification and Validation of Core Genes Involved in the Development of Papillary Thyroid Carcinoma via Bioinformatics Analysis

Table 3

KEGG and Reactome pathway enrichment analysis of differentially expressed genes in PTC.

Expression	Category	ID	Term	Count	value
Downregulated	KEGG_PATHWAY	hsa04978	Mineral absorption	6	2.90E-03
	KEGG_PATHWAY	hsa04918	Thyroid hormone synthesis	7	3.80E-03
	KEGG_PATHWAY	hsa04350	TGF-beta signaling pathway	6	3.50E-02
	KEGG_PATHWAY	hsa00350	Tyrosine metabolism	4	3.90E-02
	KEGG_PATHWAY	hsa04020	Calcium signaling pathway	9	3.90E-02
Upregulated	KEGG_PATHWAY	hsa04512	ECM-receptor interaction	15	1.10E-08
	KEGG_PATHWAY	hsa04510	Focal adhesion	17	2.50E-05
	KEGG_PATHWAY	hsa04115	p53 signaling pathway	9	1.60E-04
	KEGG_PATHWAY	hsa05205	Proteoglycans in cancer	15	2.50E-04
	KEGG_PATHWAY	hsa04151	PI3K-Akt signaling pathway	17	7.20E-03
Downregulated	REACTOME_PATHWAY	R-HSA-5661231	Metallothioneins bind metals	6	2.33E-05
	REACTOME_PATHWAY	R-HSA-5660526	Response to metal ions	6	1.03E-04
	REACTOME_PATHWAY	R-HSA-3560782	Diseases associated with glycosaminoglycan metabolism	7	0.001726
	REACTOME_PATHWAY	R-HSA-8851708	Signaling by FGFR2 IIIa TM	5	0.001887
	REACTOME_PATHWAY	R-HSA-2129379	Molecules associated with elastic fibres	6	0.002228
Upregulated	REACTOME_PATHWAY	R-HSA-1474244	Extracellular matrix organization	35	1.39E-08
	REACTOME_PATHWAY	R-HSA-3000171	Nonintegrin membrane-ECM interactions	14	6.32E-08
	REACTOME_PATHWAY	R-HSA-6785807	Interleukin-4 and 13 signaling	26	7.33E-08
	REACTOME_PATHWAY	R-HSA-216083	Integrin cell surface interactions	16	1.25E-07
	REACTOME_PATHWAY	R-HSA-3000170	Syndecan interactions	9	1.29E-06

Abbreviations: KEGG: Kyoto Encyclopedia of Genes and Genomes; PTC: papillary thyroid carcinoma.