Research Article
Correlation of TSHR and CTLA-4 Single Nucleotide Polymorphisms with Graves Disease
Table 2
Genotype distribution of TSHR and CTLA-4 gene and Hardy-Weinberg equilibrium test.
| | SNPs | Case group () | Control group () | | | HWE () | | (%) | (%) |
| | TSHR | rs179247 (A>G) | | | | | 0.80 | | A | 895 (74.96) | 782 (63.06) | 40.16 | <0.001 | | | G | 299 (25.04) | 458 (36.94) | | | AA | 342 (57.29) | 248 (40.00) | 39.44 | <0.001 | | | AG | 211 (35.34) | 286 (46.13) | | | GG | 44 (7.37) | 86 (13.87) | | | rs2284722 (G>A) | | | | | 0.06 | | G | 833 (69.77) | 937 (75.56) | 10.31 | 0.001 | | | A | 361 (30.23) | 303 (24.44) | | | GG | 291 (48.74) | 345 (55.65) | 12.97 | 0.002 | | | AG | 251 (42.04) | 247 (39.84) | | | AA | 55 (9.22) | 28 (4.51) | | | rs12101261 (T>C) | | | | | 0.56 | | T | 872 (73.03) | 756 (60.97) | 39.97 | <0.001 | | | C | 322 (26.97) | 484 (39.03) | | | TT | 320 (53.60) | 234 (37.74) | 38.60 | <0.001 | | | CT | 232 (38.86) | 288 (46.45) | | | CC | 45 (7.54) | 98 (15.81) | | | rs4903964 (A>G) | | | | | 0.29 | | A | 824 (69.01) | 701 (56.53) | 40.49 | <0.001 | | | G | 370 (30.99) | 539 (43.47) | | | AA | 279 (46.73) | 205 (33.06) | 41.47 | <0.001 | | | AG | 266 (44.56) | 291 (46.94) | | | GG | 52 (8.71) | 124 (20.00) | | | rs2300525 (T>C) | | | | | 0.68 | | T | 836 (70.02) | 909 (73.31) | 3.24 | 0.072 | | | C | 358 (29.98) | 331 (26.69) | | | TT | 297 (49.75) | 335 (54.03) | 3.26 | 0.196 | | | CT | 242 (40.54) | 239 (38.55) | | | CC | 58 (9.71) | 46 (7.42) | | | rs17111394 (T>C) | | | | | 0.61 | | T | 913 (76.47) | 1001 (80.73) | 6.57 | 0.010 | | | C | 281 (23.53) | 239 (19.27) | | | TT | 355 (59.46) | 406 (65.48) | 6.55 | 0.038 | | | CT | 203 (34.00) | 189 (30.48) | | | CC | 39 (6.54) | 25 (4.04) | | | CTLA-4 | rs231804 (A>G) | | | | | 1.00 | | A | 1031 (86.35) | 1036 (83.55) | 3.72 | 0.054 | | | G | 163 (13.65) | 204 (16.45) | | | | | AA | 447 (74.87) | 432 (69.68) | 4.10 | 0.129 | | | AG | 137 (22.95) | 172 (27.74) | | | | | GG | 13 (2.18) | 16 (2.58) | | | | | rs1024161 (A>G) | | | | | 0.44 | | A | 876 (73.37) | 868 (70.00) | 3.40 | 0.065 | | | G | 318 (26.63) | 372 (30.00) | | | | | AA | 326 (54.61) | 308 (49.68) | 3.30 | 0.192 | | | AG | 224 (37.52) | 252 (40.65) | | | | | GG | 47 (7.87) | 60 (9.67) | | | | | rs231726 (A>G) | | | | | 0.79 | | A | 813 (68.09) | 794 (64.03) | 4.47 | 0.035 | | | G | 381 (31.91) | 446 (35.97) | | | | | AA | 283 (47.40) | 256 (41.29) | 4.75 | 0.093 | | | AG | 247 (41.37) | 282 (45.48) | | | | | GG | 67 (11.23) | 82 (13.23) | | | | | rs10197319 (C>T) | | | | | 0.45 | | C | 937 (78.48) | 938 (75.65) | 2.76 | 0.097 | | | T | 257 (21.52) | 302 (24.35) | | | | | CC | 367 (61.48) | 351 (56.61) | 3.00 | 0.223 | | | CT | 203 (34.00) | 236 (38.07) | | | | | TT | 27 (4.52) | 33 (5.32) | | | |
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HWE: Hardy-Weinberg equilibrium; . |
