Research Article
Correlation of TSHR and CTLA-4 Single Nucleotide Polymorphisms with Graves Disease
Table 6
Correlation between TSHR and CTLA-4 SNPs and clinical phenotypes.
| | | | Goiter | | | Exophthalmos | | | TRAb (U/L) | | | | SNP | Genotype | 0 | I | II | III | | | Yes | No | | | ≥1.5 | <1.5 | | |
| TSHR | rs179247 | AA | 7 | 99 | 232 | 4 | 3.67 | 0.30 | 150 | 192 | 1.11 | 0.57 | 274 | 47 | 4.23 | 0.12 | AG | 7 | 71 | 127 | 6 | | | 83 | 128 | | | 153 | 40 | | | GG | 1 | 16 | 27 | 0 | | | 19 | 25 | | | 29 | 9 | | | rs2284722 | GG | 9 | 81 | 197 | 4 | 1.10 | 0.78 | 119 | 172 | 0.41 | 0.82 | 215 | 53 | 2.72 | 0.26 | AG | 6 | 87 | 153 | 5 | | | 109 | 142 | | | 194 | 37 | | | AA | 0 | 18 | 36 | 55 | | | 24 | 31 | | | 47 | 6 | | | rs12101261 | TT | 7 | 103 | 204 | 6 | 3.14 | 0.37 | 136 | 184 | 0.17 | 0.92 | 260 | 43 | 4.84 | 0.09 | CT | 6 | 68 | 154 | 4 | | | 96 | 136 | | | 164 | 45 | | | CC | 2 | 15 | 28 | 0 | | | 20 | 25 | | | 32 | 8 | | | rs4903964 | AA | 7 | 86 | 179 | 7 | 2.61 | 0.46 | 121 | 158 | 0.32 | 0.85 | 226 | 36 | 5.60 | 0.06 | AG | 5 | 83 | 175 | 3 | | | 109 | 157 | | | 192 | 53 | | | GG | 3 | 17 | 32 | 0 | | | 22 | 30 | | | 38 | 7 | | | rs2300525 | TT | 8 | 90 | 195 | 4 | 3.48 | 0.32 | 129 | 168 | 1.62 | 0.45 | 227 | 49 | 0.11 | 0.95 | CT | 5 | 76 | 155 | 6 | | | 103 | 139 | | | 184 | 37 | | | CC | 2 | 20 | 36 | 0 | | | 20 | 38 | | | 45 | 10 | | | rs17111394 | TT | 10 | 111 | 230 | 4 | 2.87 | 0.41 | 153 | 202 | 2.24 | 0.33 | 267 | 63 | 4.42 | 0.11 | CT | 4 | 58 | 135 | 6 | | | 87 | 116 | | | 161 | 24 | | | CC | 1 | 17 | 21 | 0 | | | 12 | 27 | | | 28 | 9 | | | CTLA-4 | rs231804 | AA | 12 | 138 | 288 | 9 | 1.54 | 0.67 | 187 | 260 | 1.03 | 0.60 | 345 | 72 | 0.50 | 0.78 | AG | 3 | 45 | 88 | 1 | | | 61 | 76 | | | 102 | 21 | | | GG | 0 | 3 | 10 | 0 | | | 4 | 9 | | | 9 | 3 | | | rs1024161 | AA | 11 | 101 | 207 | 7 | 2.56 | 0.46 | 140 | 186 | 0.78 | 0.68 | 250 | 53 | 1.51 | 0.47 | AG | 2 | 69 | 150 | 3 | | | 95 | 129 | | | 174 | 33 | | | GG | 2 | 16 | 29 | 0 | | | 17 | 30 | | | 32 | 10 | | | rs231726 | AA | 9 | 86 | 184 | 4 | 0.70 | 0.87 | 123 | 160 | 0.84 | 0.66 | 218 | 46 | 0.84 | 0.66 | AG | 4 | 81 | 157 | 5 | | | 104 | 143 | | | 190 | 37 | | | GG | 2 | 19 | 45 | 1 | | | 25 | 42 | | | 48 | 13 | | | rs10197319 | CC | 12 | 108 | 239 | 8 | 4.78 | 0.19 | 157 | 210 | 0.71 | 0.70 | 282 | 58 | 0.14 | 0.93 | CT | 3 | 69 | 129 | 2 | | | 82 | 121 | | | 153 | 34 | | | TT | 0 | 9 | 18 | 0 | | | 13 | 14 | | | 21 | 4 | | |
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