Correlation of TSHR and CTLA-4 Single Nucleotide Polymorphisms with Graves Disease

Table 6

Correlation between TSHR and CTLA-4 SNPs and clinical phenotypes.

			Goiter						Exophthalmos				TRAb (U/L)
	SNP	Genotype	0	I	II	III			Yes	No			≥1.5	<1.5
TSHR	rs179247	AA	7	99	232	4	3.67	0.30	150	192	1.11	0.57	274	47	4.23	0.12
		AG	7	71	127	6			83	128			153	40
		GG	1	16	27	0			19	25			29	9
	rs2284722	GG	9	81	197	4	1.10	0.78	119	172	0.41	0.82	215	53	2.72	0.26
		AG	6	87	153	5			109	142			194	37
		AA	0	18	36	55			24	31			47	6
	rs12101261	TT	7	103	204	6	3.14	0.37	136	184	0.17	0.92	260	43	4.84	0.09
		CT	6	68	154	4			96	136			164	45
		CC	2	15	28	0			20	25			32	8
	rs4903964	AA	7	86	179	7	2.61	0.46	121	158	0.32	0.85	226	36	5.60	0.06
		AG	5	83	175	3			109	157			192	53
		GG	3	17	32	0			22	30			38	7
	rs2300525	TT	8	90	195	4	3.48	0.32	129	168	1.62	0.45	227	49	0.11	0.95
		CT	5	76	155	6			103	139			184	37
		CC	2	20	36	0			20	38			45	10
	rs17111394	TT	10	111	230	4	2.87	0.41	153	202	2.24	0.33	267	63	4.42	0.11
		CT	4	58	135	6			87	116			161	24
		CC	1	17	21	0			12	27			28	9
CTLA-4	rs231804	AA	12	138	288	9	1.54	0.67	187	260	1.03	0.60	345	72	0.50	0.78
		AG	3	45	88	1			61	76			102	21
		GG	0	3	10	0			4	9			9	3
	rs1024161	AA	11	101	207	7	2.56	0.46	140	186	0.78	0.68	250	53	1.51	0.47
		AG	2	69	150	3			95	129			174	33
		GG	2	16	29	0			17	30			32	10
	rs231726	AA	9	86	184	4	0.70	0.87	123	160	0.84	0.66	218	46	0.84	0.66
		AG	4	81	157	5			104	143			190	37
		GG	2	19	45	1			25	42			48	13
	rs10197319	CC	12	108	239	8	4.78	0.19	157	210	0.71	0.70	282	58	0.14	0.93
		CT	3	69	129	2			82	121			153	34
		TT	0	9	18	0			13	14			21	4