In Vitro Susceptibility and Florfenicol Resistance in Citrobacter Isolates and Whole-Genome Analysis of Multidrug-Resistant Citrobacter freundii

Figure 2

The circular map of pR47-309 and comparative genomics analysis with other IncHI2 plasmids. Circles 1-4 (from outside to inside) are homologous regions of R478 (BX664015.1), p112298-catA (KY270851.1), pT5282-mphA (KY270852.1), and p505108-MDR (KY978628.1) compared to those of pR47-309, while the regions without similar hits between them were left blank. Circle 5 and Circle 7 display genes encoded in the forward strand and reverse strand, respectively. Circles 8 and 9 represent the GC content and GC skew maps of pR47-309, respectively. Circle 10 shows the scale in kb. Circle 6 shows the different functional regions with different colors; conjugative transfer and MDR regions are marked in steel blue and red, respectively, which are further denoted within the related bars; heavy metal resistance regions are marked in light blue, and other functional regions are in light green.